SELE and cancer: E-selectin is mostly expressed by ECs via endothelial activation during inflammation or in the presence of cytokines.56 As a consequence, E-selectin can promote atherosclerosis and cancer metastasis progression leading to poor prognosis of disease.49,55 Gakhar et al reported that in cancer, CTCs isolated from men with castration-resistant prostate cancer exhibited significant physical (tethering and firm adhesion) interactions with E-selectin-coated surfaces.34 These interactions were diminished when E-selectin antibodies were present.34