Genes such as human leukocyte antigen (HLA) complex genes HLA-DQA2/HLA-DQB2 encoding HLA-Class II molecules [24], cancer/testis (CT) antigen XAGE1B [25] and FOLR genes, which are related to multiple cancers [26], were steadily upregulated in advanced stage. The gene discussed is XAGE1B; the disease is cancer.