As detailed in a later section, SLC7A11 promotes glucose dependency, leading to the exquisite vulnerability of cancer cells with high SLC7A11 expression (SLC7A11high) to glucose starvation (Goji et al., 2017; Koppula et al., 2017; Shin et al., 2017; Joly et al., 2020; Liu et al., 2020). Here, SLC7A11 is linked to cancer.