SLC7A11 and cancer: Consistent with this, it was shown that removing cystine from cell culture media or SLC7A11 inactivation by genetic ablation or pharmacologic inhibition induces potent ferroptosis in many cancer cells; conversely, SLC7A11 overexpression in cancer cells promotes GSH biosynthesis and ferroptosis resistance (Dixon et al., 2012; Jiang et al., 2015; Zhang et al., 2018b).