SLC7A11 and cancer: However, a recent study showed that SLC7A11 overexpression does not promote glycolytic flux and that 2-deoxyglucose (2DG), a glycolysis inhibitor, even rescues glucose starvation-induced cell death in SLC7A11high cancer cells (the underlying mechanism will be described below) (Koppula et al., 2017; Shin et al., 2017).