SLC7A11 and cancer: Finally, it was shown that radiation can induce SLC7A11 expression (Xie et al., 2011; Lei et al., 2020), and SLC7A11 overexpression promotes radioresistance, whereas SLC7A11 inhibition enhances radiosensitivity in cancer cells or tumors (Cobler et al., 2018; Nagane et al., 2018; Lei et al., 2020); importantly, the radioresistance caused by SLC7A11 overexpression was largely abolished under ferroptosis inhibitor treatment (Lei et al., 2020), suggesting that SLC7A11 promotes radioresistance mainly through inhibiting ferroptosis.