GLS and cancer: Correspondingly, the cellular phenotypes in SLC7A11high cancer cells in response to glutamine or glucose deprivation seem somewhat different: while glutamine deprivation (or glutaminase inhibition) mainly suppresses the cell growth in SLC7A11high cancer cells (which is in line with anaplerosis defects in these cells) (Romero et al., 2017) (Fig. 4C), glucose starvation induces rapid cell death in SLC7A11high cancer cells (consistent with drastic redox system collapse in this context) (Goji et al., 2017; Koppula et al., 2017; Shin et al., 2017; Liu et al., 2020) (Fig. 4E).