SLC7A11 and central nervous system cancer: Consistent with this, SLC7A11 is overexpressed in multiple cancer types, including lung cancer, TNBC, PDAC, renal cell carcinoma, liver cancer, and glioma, and its high expression often correlates with poor prognosis (Timmerman et al., 2013; Ji et al., 2018; Koppula et al., 2018; Zhang et al., 2018a; Zhang et al., 2018b; Badgley et al., 2020).