OTUB1, a DUB of the ovarian tumor (OTU) family, was identified as a SLC7A11-interacting protein which stabilizes SLC7A11 by preventing SLC7A11 from undergoing ubiquitination and proteasomal degradation (Fig. 2) (Gan, 2019; Liu et al., 2019). This evidence concerns the gene SLC7A11 and ovarian neoplasm.