As antitumor effects of combined gefitinib and trastuzumab or cetuximab and trastuzumab treatment on head and neck SCC (HNSCC) were demonstrated in vitro (48,49), those few oral cancer patients displaying HER2 overexpression/amplification may possibly benefit from anti-HER2 therapy. The gene discussed is ERBB2; the disease is lip and oral cavity carcinoma.