SLC16A1 and neoplasm: have engineered porous Zr (IV)‐based porphyrinic metal‐organic framework (MOF) nanoparticles with α‐cyano‐4‐hydroxycinnamate, which is able to reduce the extrinsic lactate uptake by inhibiting the expression of monocarboxylate transporter 1 (MCT1) on cancer cells, thus restraining lactate‐fueled aerobic respiration.[15] Moreover, this strategy is also capable of enhancing PDT due to the reduced oxygen consumption and mitigated tumor hypoxia after respiration inhibition.