[25, 26, 27] However, it is known that the functions of macrophages, including phagocytosis, antigen processing, and antigen presentation, depend on M1 macrophages,[28, 29, 30] while the tumor‐associated macrophages (TAMs) are domesticated to M2 phenotypes.[31] Therefore, to fully capitalize the effect of CD47‐mediated phagocytosis enhancement and to maximize the capacity of macrophages for cancer therapy, delivery of cytokines, such as Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), to promote repolarization of macrophages towards M1 is a promising strategy.[32, 33, 34]. This evidence concerns the gene CD47 and neoplasm.