Genes targeted by PPARγ encode many of the proteins implicated in thepathogenesis of PAH including ET-1, IL-6 and adiponectin.62,81 Inaddition, reduced PPARγ expression has been observed in lungs and circulation ofPAH patients.82 Thus, there is increasing evidence that gene regulation by PPARγ plays animportant role in PAH; indeed, PPARγ agonists have demonstrated therapeuticpotential for PAH in preclinical studies.81 Here, EDN1 is linked to pulmonary arterial hypertension.