TMS is a selective, potent CYP1B1 inhibitor, andits beneficial effects on several metabolic diseases, including tumorigenesis,hypertension, atherosclerosis and adipogenesis, have been determined in animal models.118 As discussed earlier, TMS has also shown to have therapeutic effects inanimal model of PH, including obesity-induced PH.7,8 CYP1B1 inhibition has also beenexplored clinically as a therapeutic target. The gene discussed is CYP1B1; the disease is obesity due to melanocortin 4 receptor deficiency.