CYP1B1 and pulmonary arterial hypertension: We have shown that CYP1B1 is also highlyexpressed in adipose tissue, and thoracic adipose tissue from obese miceproduces 16OHE1.7 This may contribute to the pulmonary hypertensive phenotype of obese miceas TMS can prevent the development of PH in these animals.7 The close proximity of thoracic fat to the right ventricle and pulmonarycirculation may facilitate interactions with adipose-derived estrogens andcreate a microenvironment that leads to the development of PAH and/or mediatesPAH disease progression.