CYP1B1 and obesity due to melanocortin 4 receptor deficiency: CYP1B1is highly expressed in white adipose tissue in humans, and its expressionincreases upon adipogenic stimulation.119 A review of obesity-related genome-wide sequencing studies indicated thatCYP1B1 was one of three highest scoring genes associated with obesity.120 Animal models further indicate a role for CYP1B1 in obesity.