BMPR2 and pulmonary arterial hypertension: In a smallproof-of-concept study (NCT02911844), fulvestrant administration resulted in ahigher 6MWD, increased stroke volume and a decrease in 16OHE2 levels inpostmenopausal women with PAH.172 The reduction in 16OHE2 may account for some of the beneficial effectsobserved as this estrogen metabolite has previously been linked to PPHTN.107 Combined administration of fulvestrant and anastrozole has also been shown toresult in a marked improvement in hemodynamics and pulmonary vascular remodelling ina BMPR2 transgenic mouse model of PAH.110