CASP8 and Lymphadenopathy: As expected, Ripk1K376R/K376RCasp8−/−Ripk3−/− and Ripk1+/+Casp8−/−Ripk3−/− mice developed the lymphadenopathy that is associated with caspase-8 deficiency [42, 43] (Fig. S4H) and therefore were not aged beyond 11–13 weeks.