For example, the expression of IL-12 can endow CAR T cells with better in vivo proliferation and persistence;109,110 the overexpression of CXCR2 can improve the chemotaxis of T cells to tumor tissues;111 and the construction of PD1-CD28 chimeric receptors can transform immunosuppressive signals into activated T cell signals.105 With the specificity and flexibility of antibodies combined with the long-term survival and efficient killing ability of T cells, CAR T cells hold great potential for diseases other than tumors. The gene discussed is CD28; the disease is neoplasm.