This novel CAR T cell, termed 1928zT2 CAR T, completely eradicated leukemia in three R/R ALL patients.30 In another trial, Li et al.31 treated ten R/R ALL patients with second-generation CAR T-19 cells modified with the CD28 or 4-1BB costimulatory motif. This evidence concerns the gene CD28 and acute lymphoblastic leukemia.