EGFR, also known as human epidermal receptor 1 (HER1), is a receptor tyrosine kinase expressed in both epithelial cells and epithelium-derived malignancies.75–77 In addition, the gene amplification and mutation of EGFR can result in abnormal cell proliferation and survival, metastasis, and tumor-induced neoangiogenesis.78 To test the feasibility of EGFR-targeted CAR T therapy for different epithelium-derived tumors, many clinical trials have been conducted. This evidence concerns the gene EGFR and neoplasm.