To test our hypothesis that a decrease in or the loss of STING in CLL cells might lead to increased BCR signaling to support CLL growth, we generated a novel STINGKO/Eμ-TCL1 CLL mouse model by crossing B cell-specific STINGKO mice with Eμ-TCL1 mice (Fig. 8c) and purified CD19+B220lowCD5+ CLL cells from CLL-bearing STINGWT/Eμ-TCL1 and STINGKO/Eμ-TCL1 mice (Fig. S13A). This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.