In a previous report14, differentially methylated regions (DMRs) between M1 and M2 showed that the tumor-suppressor genes, such as RASSF1, RUNX3, HIC1, or APC, were hypermethylated in M2, namely, in YSTs (Fig. 1b and Supplementary Data 3). The gene discussed is RUNX3; the disease is neoplasm.