We identified two cases of spastic paraplegia (SPG), specifically SPG15 (ZFYVE26) and SPG7 (SPG7), with SPG15 showing a bigger and broader phenotypic onslaught compared to SPG7 in the form of seizures, hearing loss, and cerebellar atrophy. This evidence concerns the gene ZFYVE26 and Cerebellar atrophy.