In our study, irisin concentrations were lower in sarcopenic patients with cirrhosis than in nonsarcopenic patients with cirrhosis (32.40 pg/ml [IQR: 18.70, 121.26] vs. 288.07 pg/ml [IQR: 176.42, 359.58], p < 0.001). Here, FNDC5 is linked to Cirrhosis.