On the other hand, we should be aware that in the patients without sarcopenia, serum irisin concentrations were 264.15 pg/ml (IQR: 157.49, 358.95) for Child–Pugh A, 320.00 pg/ml (IQR: 210.39, 373.09) for Child–Pugh B, and 244.54 pg/ml (IQR: 143.18, 386.45) for Child–Pugh C (Table 3, Fig. 1). The gene discussed is FNDC5; the disease is sarcopenia.