The ACE and ACE2 expression data underscores this notion; we show that cortical expression of ACE and ACE2 is decreased in Px-UNx, whereas compartmentalized gene expression analysis show increased expression of ACE and ACE2 in glomeruli and decreased expression in the tubulointerstitium and whole kidneys in STZ-induced diabetes in rats59. This evidence concerns the gene ACE2 and diabetes mellitus.