H2BC3 and osteosarcoma: A study of GCTBs and osteosarcomas using methylation array attracted our attention, because it identified HIST1H2BB as the most differentially methylated gene between osteosarcomas with and without G34W mutation15 and because this gene was found within G34-hyper-DMRs and among the large-positive LF genes for G34 subgroup-specific ICs in our study (Tables S3 and S4).