These data indicate that PIEZO1 acts as a central functional point to form an integrated mechanical-regulation molecule network, here giving rise to the hypothesis that a feedback mechanism where the increasing tumour tissue stiffness caused by abnormal regulation of cell growth activates the PIEZO1 ion channel and multiple ECM-related pathways that are downstream, in turn modulating cell proliferation and TME remodelling to increase tissue pressure. The gene discussed is PIEZO1; the disease is neoplasm.