CD274 and lung adenocarcinoma: Consistent conclusion has been reported in another retrospective study: a total of 56 patients with advanced lung adenocarcinoma, who received first-line pemetrexed-based chemotherapy, the median PFS of PD-L1 positive patients (5% cut-off) was significantly longer compared to the negative (6.4 vs. 3.9 months; P = 0.008), although whether the patients received pemetrexed maintenance therapy has not been described24.