Furthermore, after we transplanted different numbers of MLL-AF9 knock-in BM cells into lethally irradiated recipient mice, we determined that the risk for primitive hematopoietic stem/progenitor cells (HSPC) of being transformed into leukemia stem cells, mentioned as cell-transforming potential (CTP), was tenfold higher when mice consumed a HFD (Fig. 1F). Here, KMT2A is linked to leukemia.