We identified the 5′-nucleotidase, cytosolic II (NT5C2) and fucosyltransferase 8 (FUT8) genes which were associated with susceptibility to T2D not only SNPs but also DNA promoter hypermethylation in human T2D, and gene expression inhibition following by DNA methylation in T2D model mice (Fig. 1). Here, FUT8 is linked to type 2 diabetes mellitus.