We found that sirtuin signalling pathway63, cardiac hypertrophy signalling, estrogen receptor signalling, insulin secretion signalling64 and signalling by Rho Family GTPases were upregulated in DJ-1−/− mice while hepatic fibrosis signaling pathway, endothelin-1 signalling, ephrin receptor signalling, fMLP signalling in neutrophils were down regulated based on Z-score (Fig. 6c). This evidence concerns the gene ESR1 and Hepatic fibrosis.