Treatment of Mmp-8 inhibitor on the brain of aged normal and leucine-rich repeat kinase 2 (LRRK2) G2019S PD model mice systemically stimulated with LPS suggested that Iba-1 positive microglia and GFAP-positive astrocytes were decreased which were activated by LPS in aged normal and PD mice model66. The gene discussed is AIF1; the disease is Parkinson disease.