As assessed by the bioluminescence of cancer cells, CD47 mAbs treatment showed only mild anti-metastasis effects (Fig. 5b); in contrast, the hNVs therapy significantly reduced the lung metastasis (Fig. 5c, d), which can be attributed to the enhanced interaction with cancer cells in the circulatory system and the repolarized antitumor M1 type macrophages. Here, CD47 is linked to cancer.