To contribute further insight into the physiological players that enhance or control white matter damage during the chronic stage of infection, we conducted scRNAseq analysis of CD45+ cells present within the spinal cord at day 21 p.i. We found enriched populations of CD4+ T cells, effector CD8+ T cells, memory CD8+ T cells, and plasma cells (Fig. 9A and B). The gene discussed is PTPRC; the disease is infection.