CD4 and infection: To investigate the role of EZH2 in the CD4 T cell response during acute infection, we first adoptively transferred naive LCMV-specific SMARTA (SM) cells, which express a transgenic T cell receptor specific for the LCMV glycoprotein epitope I-AbGP66-77, into wild-type (WT) C57BL/6J recipient mice and subsequently infected the recipients with LCMV Armstrong strain virus.