These lesions were similar to serous tubal intraepithelial carcinomas (STICs) and early high-grade serous carcinomas previously described in mouse models with combined inactivation of Trp53 and Brca1, Brca2 or Pten (Perets et al., 2013), or an amino-terminal truncated version of SV40 large T antigen (T121), which inactivates all members of the RB family (Rb1, p107 and p130) (Zhang et al., 2019). Here, BRCA1 is linked to serous adenocarcinoma.