TP53 and prostate carcinoma: It has been shown to work through AMPK to inhibit mTOR and induce autophagy in human cancer cells with wild type p53 [86]..However, In prostate cancer cells with mutant p53, DHA was observed to induce autophagy through the creation of mitochondrial reactive oxygen species that results in the inactivation of AKT and mTOR also resulting in the activation of autophagy (Fig. 5) [87].