HBS1L, also known as eRF3c, encodes protein belongs to eRF3 family member which has multifunctional properties including translation termination [25], mRNA decay [26] etc. It’s reported that Polyglycine expansions in eRF3 regulating its expression and/or changing the protein function are associated with gastric cancer susceptibility [27]. The gene discussed is HBS1L; the disease is gastric cancer.