Furthermore, while we investigated the involvement of S1P and its immunoregulatory roles in the two commonest forms of dementia (AD and VaD), it is probable that S1P may be of relevance to other neurodegenerative disorders whereby neuroinflammation is a suspected factor and player, for example, in Lewy Body Dementias and Frontotemporal Dementia. Here, MBTPS1 is linked to frontotemporal dementia.