Our data showing that high expression of TTLL4 significantly correlates with brain metastasis (Fig. 1d) together with the finding that EVs derived from TTLL4 overexpressing cells contain proteins involved in the control of neoplasia, metastasis and invasion (Fig. 6) led us to analyze the effect of TTLL4plus derived EVs on malignancy of TNBC cells. The gene discussed is TTLL4; the disease is neoplasm.