Recent studies have shown, that treatment with SGLT-2 inhibitors dapagliflozin [32] or canagliflozin [33] can improve LV diastolic function in patients with type 2 diabetes, and that SGLT-2 inhibitors may play a future role in prevention and treatment of cardiovascular disease in patients with type 2 diabetes. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.