FGF23 and heart failure: We found that increasing levels of FGF-23 were associated with a decrease in MPR due to impaired perfusion during vasodilator-induced stress, further supporting the theory that microvascular disease plays an important role in the pathogenesis of cardiovascular disease and heart failure in patients with type 2 diabetes, as increased levels of FGF-23 has also been associated with an increased risk of major adverse cardiovascular events including incident heart failure in this group of patients [9].