Our data support a similar relation between FGF-23 and vascular dysfunction in patients with type 2 diabetes, however, whether the effect of FGF-23 on the vasculature is through alterations in coronary microvascular function, promotion of vascular atherosclerotic calcification, or through physiological modifications in other steps of the vasodilatory process cannot be concluded from the present study. This evidence concerns the gene FGF23 and type 2 diabetes mellitus.