In the murine heart, acute myocardial ischemia was shown to upregulate SGLT1 [18, 40], whereas permanent left anterior descending coronary artery ligation resulted in increased SGLT1 expression in the intact LV area [41], suggesting that SGLT1 might have a causal role in the development of IHD. This evidence concerns the gene SLC5A1 and myocardial ischemia.