Correspondingly, compared to individuals with apolipoprotein A1 ≥ 190 mg/dL, multivariable adjusted HR for any cancer was 1.06 (0.96–1.17) for individuals with apolipoprotein A1 of 160–189 mg/dL, 1.18 (1.07–1.30) for individuals with apolipoprotein A1 of 130–159 mg/dL, and 1.28 (1.13–1.46) for individuals with apolipoprotein A1 < 130 mg/dL (P for trend = 8 × 10−6; Fig. 2, upper right panel). The gene discussed is APOA1; the disease is cancer.