The mutated 82 genes of a large cohort of patients include the 6 genes above and also previously identified lung adenocarcinoma related genes such as KRAS, TP53, STK11, RB1, NF1, RMB10, BRAF, KEAP1, CDKN2A, SETD2, ARID1A, SMARCA4 and MGA [5]; EGFR and ERBB2 [4, 5]; and PIK3CA [5, 6]. Here, PIK3CA is linked to lung adenocarcinoma.