Indeed, elevated levels of APRIL were detected in the sera of patients with RA, systemic lupus erythematosus (SLE), IgA nephropathy and Sjögren’s syndrome (Zhao et al. 2014; Treamtrakanpon et al. 2012; Samy et al. 2017). This evidence concerns the gene TNFSF13 and systemic lupus erythematosus.