CCR5 and infection: Although a daunting goal, the scientific basis is clear: long-term remission if not eradication has been observed in the “Berlin patient”2 as well as the “London patient”3 following transplantation of bone marrow progenitor cells lacking the viral coreceptor, CCR5; and durable remission occurs in tens of thousands of PLHIV (so-called “Elite Controllers”), some of whom (“Exceptional Elite Controllers”) may have eliminated their infections through natural immunity.4,5