MAPK10 and brain ischemia: JNK3 has a key role in cerebral ischemia/reperfusion, in particular through the assembly of the Dvl-1-β-arrestin-2-JNK3 signaling module [104], and it has been proved that inhibiting JNK3 through Akt1 has a neuroprotective effect on the hippocampal CA1 pyramidal neurons after the induction of transient global brain ischemia [105,106].