MAPK10 and temporal lobe epilepsy: Different studies have also proved that JNK3 is associated with kainic acid (KA)-induced temporal lobe epilepsy; in fact, JNK3 knockout mice show decreased neuronal degeneration after KA injection [32], and pharmacological blockage of JNK3 has a neuroprotective effect against the neurotoxicity induced by KA [111], pointing to JNK3 as a key mediator of cell death during epileptogenesis.