Suppressor of cytokine signaling 1 (SOCS1), the key negative controller of Janus kinase/Signal transducers and activators of transcription (JAK/STAT) signaling pathway [10], has been reported as the main target of miR-155 in peripheral blood mononuclear cells (PBMCs) of RA patients [2,11]. Here, SOCS1 is linked to rheumatoid arthritis.