IGF1 and diabetes mellitus: Recently, various additional attempts have been made to enhance the health-promoting properties of rice plants, including the development of transgenic rice for allergy immunotherapy [33], the engineering of transgenic rice seeds to produce a type II-collagen (CII) tolerogenic peptide to tackle anti-CII autoimmune diseases [34] or human insulin-like growth factor 1 for treating diabetes [35], and the development of gamma-aminobutyric acid (GABA)-enriched rice to reduce hypertension [36].