Although the exact molecular mechanism of how these two miRNAs affect the pathophysiology of severe neutrophilic asthma remains unknown, recent findings point towards their role in the development of other important disorders: in the lungs of tuberculosis patients, miR-223 upregulates miR-142-3p expression as part of the ‘miR-223-CEBP-β-LMO2-miR-142’ pathway [45] and controls neutrophil recruitment as well as neutrophil-driven inflammation [39]. The gene discussed is CEBPA; the disease is tuberculosis.