In different solid cancers, including non-small cell lung cancer (NSCLC) [174] and colorectal cancer (CRC) [175], NK cell have been demonstrated to acquire pro-angiogenic phenotype and function, described as CD56brightCD16-CD9+CD49a+VEGF+CXCL-8+IFN-γ low, similar to dNKs [176,177,178,179,180]. This evidence concerns the gene ITGA1 and non-small cell lung carcinoma.