In this scenario, a persistent insult and time-dependent accumulation of cellular damags; the chronic release of senescence-associated secretory phenotype (SASP); and factors such as IL-6, RANTES/CCL5, IL-8/CXCL8, CXCL1, together with an impaired clearance and accumulation of senescent cells, lead to tissue dysfunction and chronic inflammation [76,77,78,79,80,81,82]. The gene discussed is CCL5; the disease is inflammatory response.