HNF4A and esophageal adenocarcinoma: Conversely, overexpression of HNF4A in adult mouse esophageal explants induced a columnar-like expression profile [184] and HNF4A alone was sufficient to drive chromatin opening and activation of a esophageal adenocarcinoma-like chromatin signature when expressed in normal human epithelial cells [185], suggestive of a key role for HNF4A in promoting GIAC initiation and progression.