Hence, while the tumor suppressive functions of HNF4A are evident in liver and are in accordance with its role in the maintenance of hepatocellular identity and quiescence, the increased HNF4A expression and tumor promoting actions in GIAC might suggest that, in certain types of cancer, the typical activities of HNF4A as gatekeeper of cell identity are re-rooted towards other functions which, on the contrary, support tumorigenesis. Here, HNF4A is linked to cancer.