NFKB1 and Alzheimer disease: Given that keratinocytes, a major cell type in epidermis, contribute to AD pathogenesis and that up-regulation of cytokines including TSLP, IL-10, IL-13, and IL-25 is dependent on NF-κB activation in keratinocytes [32,33,34,35], we next investigated whether CA-PH modulates the NF-κB signaling pathway in HaCaT keratinocytes.