Further underscoring the increased aggressiveness of AML with Evi1 overexpression, LCFlt3-ITD/Npm1c_Evi1 contained a much higher proportion of immature (Gr-1−) cells within the myeloid (CD11b+) compartment than LCFlt3-ITD/Npm1c_vec (Figure 2c and Figure S2b). The gene discussed is RUNX1; the disease is acute myeloid leukemia.