To determine the effects of atRA, and its interactions with the expression of Evi1, on viability, apoptosis, differentiation, and stem cell-related properties of LCs from Flt3-ITD/Npm1c-driven AML, BM LCFlt3-ITD/Npm1c_vec and LCFlt3-ITD/Npm1c_Evi1 were treated with atRA or solvent and subjected to appropriate assays. The gene discussed is MECOM; the disease is acute myeloid leukemia.