In dogs with mild IBD (group I), the number of VIP-positive nerves in the evaluated segments of the intestinal tract was slightly lower compared to the control dogs (Figure 1I), but statistically significant differences between these groups were not observed (Table 1) The average number of intramucosal VIP-LI nerves per observation field in dogs with mild IBD amounted to 23.01 ± 2.10 in the duodenum, 24.49 ± 1.91 in the jejunum and 24.24 ± 2.47 in the descending colon (Table 1). This evidence concerns the gene VIP and inflammatory bowel disease.