In the experimental model of MS, MOG-EAE mice (myelin oligodendrocyte glycoprotein experimental autoimmune encephalomyelitis), overall peptidase proteasome activity during the acute phase of EAE correlated with increased levels of LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i) subunits in neurons and glia. Here, MOG is linked to myeloid sarcoma.