The effects of BCP obtained from curry leaf, a commonly used spice, on P-glycoprotein (P-gp) transport and CYP3A4 metabolism were evaluated in L-MDR1 (LLC-PK1 cells transfected with human MDR1 gene) and Caco-2 (human colon carcinoma) cells and CYP3A4 activity in pooled human liver microsomes [162]. This evidence concerns the gene ABCB1 and colon carcinoma.