The inhibitory effects of BCP on TLR4/RAGE, HMGB1-TLR4, NF-kB, PI3K/Akt, AMPK/CREB, ERK1/2/JNK1/2, SIRT1/PGC-1α, TLR4/NF-kB pathways are suggestive of its pharmacological and molecular mechanism of its potential usefulness in DM and its complications. Here, NFKB1 is linked to diabetes mellitus.