During this phase, the T-lymphocytes, now mature and ready to interact with the tumor cells, are able to directly recognize the TAA presented to them directly by the tumor cells, through the MHC of class I. This unique interaction, which takes place between the TAA presented by the class I MHC and the T-Cell receptor (TCR) present on the membrane of the T-lymphocytes, is sufficient to activate the T-lymphocyte and cause the destruction of the tumor cell. Here, HLA-C is linked to neoplasm.