Using a multivariate logistic regression analysis (Table 9), KDIGO stage 3 AKI (OR, 7.0; CI, 2.5–19.8), serum phosphate ≥3.1 mmol/L (OR, 1.2; CI, 1.1–1.3) and prothrombin index ≤ 68% (OR, 1.04; CI, 1.02–1.06) were the independent variables on admission significantly associated with the risk of death in the ICU. This evidence concerns the gene F2 and acute kidney injury.