Moreover, RASSF1A, FHIT, 14-3-3, TMS1, CDH1, CHFR, GSTP, TIMP3, SEMA3B, RAR-β, MGMT, BLU, THBS1, RIZ1, OPCML and PTGS2 have also been mentioned in CCA subtypes or cell lines. The gene discussed is CDH1; the disease is cholangiocarcinoma.