The chemoprotective role in HCC would be achieved through the following cellular processes: PPARγ will be produced at the beginning, then heterodimers will form between PPARγ and the retinoid X receptor, which will attract coactivators and bind to the peroxisome proliferator response structures and, thus, regulate the genes of lipid metabolism, anti-inflammatory, and anti-cell proliferative function [114]. The gene discussed is PPARG; the disease is hepatocellular carcinoma.