MTOR and steatosis: Phytosomal curcumin has been shown experimentally to have effects on peroxisome proliferator-activated receptor gamma (PPARγ) anti-inflammatory activation, pro-inflammatory NF-κB inhibition, suppression of mammalian target of rapamycin (mTOR) deactivation oncogene, improvement of hepatic histopathology (steatosis and necroinflammation), and reduction in volume HCC [106].